Biomaterials for Tissue Engineering
Antonios G Mikos (Rice University)
Biomaterial-based strategies for tissue engineering span a vast spectrum from the production of scaffolds tailored with appropriate mechanical properties and degradation kinetics to serve transiently as a bridge to tissue formation to the leverage of biomaterials for the controlled delivery of biological signals to regenerate tissue in specific sites in the body. For example, our laboratory has developed a variety of biodegradable polymers for the controlled delivery of bioactive agents and/or progenitor cell populations to promote regeneration of tissues such as bone and cartilage. We have also applied engineered culture of cell populations on three-dimensional scaffolds toward the development of biologically active hybrid scaffold/extracellular matrix constructs for regenerative medicine applications as well as testing of anticancer drugs. This talk will present recent examples of biomaterial-based approaches for the development of tissue engineering technologies to meet clinical needs.