The Huck Institutes of the Life Sciences

Exploiting the RNA virus quasispecies for antiviral and vaccine development

Craig Cameron (Pennsylvania State University)

When: Tuesday, December 2, 2008 - 4:00pm - 5:30 pm
Where: Berg Auditorium, 100 Life Sciences
Name: Pamela Mitchell
Phone: 865-5802


My laboratory is interested in defining the molecular details of genome replication in positive-strand RNA viruses and identifying components of this process suitable for antiviral drug development. Current research includes:

  • Understanding the molecular mechanisms governing specific and efficient replication of poliovirus genomes by its RNA-dependent RNA polymerase (RdRP), 3D pol
  • Using a structural model for the ternary complex of 3Dpol to guide mutational analysis of this enzyme
  • Defining physical and functional interactions between nonstructural proteins in hepatitis C virus

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