Microbial Dark Matter and Beyond the Human Exome
Edward Rubin (U.S. Department of Energy)
Edward M. "Eddy" Rubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Department in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI's involvement in the Human Genome Project (HGP). Under his leadership, the JGI completed the sequencing and analysis of human chromosomes 5, 16 and 19 (~13% of the human genome). After completion of the HGP, Dr Rubin has led the reorientation of the JGI as a next-generation genome science center, applying genomics to studies related to bioenergy and the environment, sequencing and analyzing the genetic code of thousands of plants, fungi and microbes.
Dr. Rubin's research has involved the development and application of computational and biological approaches for studying genomes. His early work focused on decoding the human genome. He then championed its functional exploration, harnessing sequence comparisons between species for the discovery of genes and non-coding sequences of pivotal evolutionary and biomedical importance. Other related work included sequencing and analysis of regions of the genomes of extinct cave bears and Neanderthals. More recently, he has expanded the frontiers of the new science of metagenomics, deriving important insights from his investigations of microbial communities inhabiting environments ranging from gutless ocean-dwelling worms to cow rumen.
He has organized and chaired major genomics meetings, sits on the scientific advisory boards of several technology companies and public research organizations, and is a member of the Jackson Laboratory Board of Trustees.