The Huck Institutes of the Life Sciences

Genetically defective mice shed new light on treating depression

Researchers led by Dr. Bernhard Luscher have characterized a new mouse model of depression that points to a new cause of Major Depressive Disorder in humans. The mice suffer from a genetic deficiency in GABA-A-receptors, and they exhibit hormonal and pharmacological properties indicative of a form of depression known as Melancholic Depression.