The ultimate goal of Mao lab is to help develop better therapies and cures for patients with mental illnesses. To achieve this goal, our lab focuses on understanding the mechanisms that lead to abnormal behaviors. In particular, we utilize cross-disciplinary techniques to overcome challenges that others have not been able to address. The research of our lab focuses on the mechanisms that regulate neurogenesis using mouse models and human stem cells. We will determine how abnormal NPC proliferation and differentiation may lead to mental illnesses. Our long-term goal is to use the reagents, experimental systems, and mouse models that we develop to further screen novel drugs that can reverse the behavior phenotype in our mouse model and eventually provide new treatments for patients with psychiatric disorders.