Center for Cellular Dynamics Publications
Using a technique known as Bimolecular Fluorescence Complementation (BiFC), Zhi-Chun Lai and his lab have directly visualized the activation of the Hippo (Hpo) tumor-suppressor pathway in living cells.
A team led by Melissa Rolls has found that a mutation in a single gene can completely shut down the process by which axons, nerve-cell components responsible for sending signals to other cells, regenerate after being damaged.
Researchers have identified in mice a protein that is necessary for maintaining behavioral flexibility, the ability to adapt to changing circumstances; their findings may offer new insights for addressing such human afflictions as autism and schizophrenia, in which this ability is significantly impaired.
A team of scientists led by Huck Institutes faculty member Gong Chen has developed a new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction.
Nerve pathway for combating axon injury and stress may hold benefits for individuals with neurodegenerative disorders
Researchers from the Huck Institutes' Center for Cellular Dynamics " led by Center director Melissa Rolls " have found that a neuroprotective pathway initiated in response to injured or stressed neural axons serves to stabilize and protect the nerve cell against further degeneration.
Gong Chen and graduate students Joseph Cichon and Chicheng Sun " working with researchers from Fudan University in Shanghai, China " identify a signaling pathway and roles of cofilin rods that may underlie neurodegeneration and brain aging.